SAFB1- and SAFB2-mediated transcriptional repression: relevance to cancer.

نویسندگان

  • Elaine A Hong
  • Hannah L Gautrey
  • David J Elliott
  • Alison J Tyson-Capper
چکیده

SAFB1 (scaffold attachment factor B1) and a second family member SAFB2, are multifunctional proteins implicated in a variety of cellular processes including cell growth, apoptosis and stress response. Their potential function as tumour suppressors has been proposed based on well-described roles in tran-scriptional repression. The present review summarizes the current knowledge of SAFB1 and SAFB2 proteins in transcriptional repression with relevance to cancer.

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عنوان ژورنال:
  • Biochemical Society transactions

دوره 40 4  شماره 

صفحات  -

تاریخ انتشار 2012